Description

Duvelisib (R Enantiomer) is the single, pharmacologically active R-enantiomer of the phosphatidylinositol 3-kinase (PI3K) delta and gamma inhibitor Duvelisib. This high-purity enantiomer is critical for advanced pharmaceutical research and development, particularly in the study of isoform-specific inhibition and metabolic pathways. It is primarily utilized by medicinal chemists, pharmacologists, and process development scientists within the pharmaceutical and biotechnology sectors for preclinical studies, analytical reference standards, and as a key intermediate in the synthesis of targeted therapies.

Application

• Pharmaceutical Reference Standard: Serves as a certified analytical standard for quality control and method validation in API and finished drug product testing.
• Medicinal Chemistry Research: Used as a critical building block or intermediate in the synthesis and optimization of novel PI3K inhibitors and targeted cancer therapies.
• Pharmacological Studies: Enables precise investigation of the R-enantiomer's specific biological activity, pharmacokinetics, and metabolic profile separate from its S-counterpart.
• Process Development & Scale-up: Acts as a benchmark for developing and optimizing enantioselective synthesis routes for active pharmaceutical ingredients (APIs).
• Biochemical Assay Development: Utilized in high-throughput screening and enzymatic assays to study PI3K delta/gamma inhibition mechanisms.

Basic Information

Product Name	Duvelisib (R Enantiomer)
CAS No.	1261590-48-0
Molecular Formula	C22H17ClN6O
Molecular Weight	416.86 g/mol
Synonyms	(R)-Duvelisib; (R)-IPI-145; (R)-8-Chloro-2-phenyl-3-[(1S)-1-(7H-purin-6-ylamino)ethyl]isoquinolin-1(2H)-one; (R)-8-Chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-1,2-dihydroisoquinolin-1-one; R-Enantiomer of IPI-145; (R)-Duvelisib free base; UNII-9V8V49E1K5 component
EINECS	Contact for details

Quality Control

Our Duvelisib (R Enantiomer) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess determination, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided and available upon request to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.