Description

5-Azido Uridine is a modified nucleoside analog featuring an azido functional group at the 5-position of the uracil base. This compound is a critical building block in bioorthogonal chemistry and click chemistry applications, enabling the specific labeling and conjugation of biomolecules. It is primarily utilized by researchers and manufacturers in the fields of pharmaceutical development, proteomics, and nucleic acid chemistry for the synthesis of probes and drug candidates.

Application

• Bioorthogonal Labeling Reagent: Used in click chemistry reactions (e.g., CuAAC, SPAAC) for the site-specific labeling of nucleic acids, proteins, and other biomolecules.
• Proteomics Research: Serves as a metabolic precursor for the incorporation of azide tags into newly synthesized RNA, facilitating pull-down assays and visualization studies.
• Antiviral & Anticancer Agent Development: Acts as a key synthetic intermediate in the research and development of novel nucleoside-based therapeutic agents.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes to study enzyme function and nucleic acid-protein interactions.
• Polymer & Materials Science: Used to functionalize surfaces or polymers via azide-alkyne cycloaddition for creating bioactive materials.
• Diagnostic Assay Development: Incorporated into oligonucleotide probes for sensitive detection systems in molecular diagnostics.

Basic Information

Product Name	5-Azido Uridine
CAS No.	1261272-24-5
Molecular Formula	C9H11N5O6
Molecular Weight	285.22 g/mol
Synonyms	5-Azidouridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-azidopyrimidine-2,4(1H,3H)-dione; 5-N3-Uridine; 5-Azido-1-β-D-ribofuranosyluracil; Uridine, 5-azido-
EINECS	Contact for details

Quality Control

Our 5-Azido Uridine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.