Description

4-Methoxy-1H-Indole-3-Carbonyl Chloride is a versatile and highly reactive chemical building block, specifically an indole derivative functionalized with a carbonyl chloride group. This compound is of significant importance in organic synthesis, particularly in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for constructing complex molecules. It is primarily needed by research chemists and process development scientists for the synthesis of novel drug candidates, advanced materials, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds with indole-based scaffolds.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators.
• Peptide Mimetics & Drug Discovery: The reactive acid chloride group enables efficient amide bond formation, making it valuable for creating peptide-like structures and combinatorial libraries.
• Material Science Research: Employed in the synthesis of organic semiconductors, dyes, and photochromic materials due to the electron-rich indole moiety.
• Academic & Contract Research: Serves as a specialized reagent for methodological development and the synthesis of complex natural product analogs in research laboratories.

Basic Information

Product Name	4-Methoxy-1H-Indole-3-Carbonyl Chloride
CAS No.	1260778-09-3
Molecular Formula	C10H8ClNO2
Molecular Weight	209.63 g/mol
Synonyms	4-Methoxyindole-3-carbonyl chloride; 1H-Indole-3-carbonyl chloride, 4-methoxy-; 4-Methoxy-1H-indole-3-carboxylic acid chloride; 3-Carboxy-4-methoxyindole chloride; 4-Methoxyindole-3-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 4-Methoxy-1H-Indole-3-Carbonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as identity, purity, and impurity profiles. Our quality management system is designed to meet the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.