Description

5-Bromo-3-Fluoro-2-Iodopyridine is a highly functionalized pyridine derivative that serves as a versatile and valuable building block in advanced organic synthesis. Its unique halogen substitution pattern makes it a critical intermediate for constructing complex molecules with precise electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, drug discovery, and the development of novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Ligand and Catalyst Development: Serves as a scaffold for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or photoactive compounds.
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira) due to the presence of bromine and iodine substituents.
• Chemical Biology Probes: Utilized to create molecular probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	5-Bromo-3-Fluoro-2-Iodopyridine
CAS No.	1260665-95-9
Molecular Formula	C5H2BrFIN
Molecular Weight	301.88 g/mol
Synonyms	2-Iodo-5-bromo-3-fluoropyridine; 3-Fluoro-5-bromo-2-iodopyridine; 5-Bromo-3-fluoro-2-iodopyridine; Pyridine, 5-bromo-3-fluoro-2-iodo-; 2-Iodo-3-fluoro-5-bromopyridine
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-Fluoro-2-Iodopyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor quality protocols to meet specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Melting Point	Contact for details
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.