Description

7-Chloro-1,2,3,4-tetrahydro-2,6-naphthyridine hydrochloride is a high-purity pharmaceutical intermediate and building block of significant importance in modern organic synthesis. Its value lies in its role as a key precursor for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. This compound is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to innovate and scale new molecular entities.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of potential drug candidates, especially in central nervous system (CNS) and oncology research.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural motif in the design and manufacture of novel APIs.
• Chemical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry & Scale-Up: Employed in route scouting and pilot-scale synthesis for clinical trial material production.
• Agrochemical Synthesis: Potential intermediate for creating new crop protection agents with specific biological activity.
• Ligand and Catalyst Development: Useful in constructing complex nitrogen-containing ligands for catalytic applications.

Basic Information

Product Name	7-Chloro-1,2,3,4-Tetrahydro-2,6-Naphthyridine Hydrochloride
CAS No.	1260664-42-3
Molecular Formula	C8H10Cl2N2
Molecular Weight	205.08 g/mol
Synonyms	7-Chloro-1,2,3,4-tetrahydro-2,6-naphthyridine HCl; 2,6-Naphthyridine, 7-chloro-1,2,3,4-tetrahydro-, hydrochloride; 7-Chloro-3,4-dihydro-2,6-naphthyridine hydrochloride; 7-Chloro-1,2,3,4-tetrahydro-2,6-naphthyridine monohydrochloride; 1260664-42-3; 7-Cl-THN HCl; Tetrahydro-2,6-naphthyridine hydrochloride derivative
EINECS	Contact for details

Quality Control

Our 7-Chloro-1,2,3,4-tetrahydro-2,6-naphthyridine hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material suitable for research use and can supply grades aligned with cGMP standards for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.