Description

5-Bromo-2,4-Difluorobenzoylchloride is a high-purity, multi-functional organic intermediate essential for advanced chemical synthesis. Its value lies in its reactive benzoyl chloride core, which is strategically functionalized with bromine and fluorine substituents, enabling precise molecular construction. This compound is critically needed by R&D chemists and process developers in the pharmaceutical, agrochemical, and advanced materials sectors to create novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the fluorine and bromine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination for complex molecule assembly.
• Polymer Chemistry: Monomer for introducing aromatic, halogenated units into high-performance polymers, influencing thermal stability and refractive index.
• Chemical Research & Development: A versatile reagent in academic and industrial labs for exploring new synthetic pathways and creating custom fluorinated compounds.

Basic Information

Product Name	5-Bromo-2,4-Difluorobenzoylchloride
CAS No.	1260654-60-1
Molecular Formula	C7H2BrClF2O
Molecular Weight	255.45 g/mol
Synonyms	2,4-Difluoro-5-bromobenzoyl chloride; 5-Bromo-2,4-difluorobenzoic acid chloride; Benzoyl chloride, 5-bromo-2,4-difluoro-; 1260654-60-1; 5-Br-2,4-F2PhCOCl
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2,4-Difluorobenzoylchloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed HPLC/GC profiles are available for each lot upon request, confirming identity, purity, and impurity levels.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.