Description

1H-Pyrrolo[3,4-C]Pyridine-5,7A-Dicarboxylic Acid, Hexahydro-, 7A-Ethyl 5-(Phenylmethyl) Ester, Hydrochloride , (3As,7As)- is a high-purity, stereochemically defined pharmaceutical intermediate of significant commercial interest. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and other therapeutic agents. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in advanced drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates targeting neurological disorders.
• API Development: Used as a precursor in the research and scale-up manufacturing of complex Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry: Employed in route scouting and the development of robust, scalable synthetic pathways for GMP production.
• Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and commercial drug substances.
• Chemical Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method validation.

Basic Information

Product Name	1H-Pyrrolo[3,4-C]Pyridine-5,7A-Dicarboxylic Acid, Hexahydro-, 7A-Ethyl 5-(Phenylmethyl) Ester, Hydrochloride , (3As,7As)-
CAS No.	1260605-35-3
Molecular Formula	C19H24N2O4 • HCl
Molecular Weight	380.87 g/mol (Free base: 344.41 g/mol)
Synonyms	(3aS,7aS)-7a-Ethyl 5-(benzyl) hexahydro-1H-pyrrolo[3,4-c]pyridine-5,7a-dicarboxylate hydrochloride; Hexahydro-1H-pyrrolo[3,4-c]pyridine-5,7a-dicarboxylic acid, 7a-ethyl 5-(phenylmethyl) ester, hydrochloride, (3aS,7aS)-; 1H-Pyrrolo[3,4-c]pyridine-5,7a(6H)-dicarboxylic acid, hexahydro-, 7a-ethyl 5-(phenylmethyl) ester, hydrochloride, (3aS,7aS)-; CAS 1260605-35-3; (3aS,7aS)- enantiomer hydrochloride salt.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral assay, NMR and MS for structural confirmation, and tests for residual solvents and moisture (KF). We provide detailed Certificates of Analysis (COA) with each shipment, ensuring full traceability and compliance with your research or cGMP requirements. Specifications can be aligned with client-specific pharmacopeial or internal standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Assay (Titration)	97.0% - 103.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.