Description

6-Chloro-4-Azaindole-2-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery. Its core value lies in its role as a versatile building block for synthesizing novel, biologically active compounds, particularly kinase inhibitors. This product is essential for research and development teams in the pharmaceutical, biotechnology, and agrochemical sectors who require reliable, high-quality intermediates for their synthetic programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted small-molecule drugs, especially kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic candidates.
• Agrochemical Development: Serves as a building block for creating novel active ingredients with potential herbicidal or pesticidal properties.
• Biochemical Tool Compound Synthesis: Employed in the preparation of specialized probes and inhibitors for biological pathway analysis and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations engaged in custom synthesis and process development for client projects.

Basic Information

Product Name	6-Chloro-4-Azaindole-2-Carboxylic Acid Ethyl Ester
CAS No.	1260386-97-7
Molecular Formula	C10H9ClN2O2
Molecular Weight	224.64 g/mol
Synonyms	Ethyl 6-Chloro-1H-pyrrolo[3,2-c]pyridine-2-carboxylate; 6-Chloro-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid ethyl ester; 6-Chloro-4-aza-indole-2-carboxylic acid ethyl ester; 4-Azaindole-2-carboxylic acid, 6-chloro-, ethyl ester; AZD-1480 Intermediate; GDC-0941 related intermediate
EINECS	Contact for details

Quality Control

Our 6-Chloro-4-Azaindole-2-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.