Description

tert-Butyl 2-(Aminomethyl)-4,4-difluoropiperidine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a difluorinated piperidine scaffold with a protected amine group. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel bioactive molecules with enhanced metabolic stability and membrane permeability. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new drug candidates, particularly in the areas of central nervous system (CNS) and oncology therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce the difluoropiperidine motif, which can improve drug-like properties.
• Protease Inhibitor Development: Serves as a precursor for compounds designed to inhibit specific enzymes, such as kinases or proteases.
• CNS Drug Discovery: Employed in creating novel molecules for neurological disorders, leveraging the piperidine core common in many neuroactive drugs.
• Chemical Biology Probes: Utilized to develop tool compounds for investigating biological processes and target validation.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	tert-Butyl 2-(Aminomethyl)-4,4-difluoropiperidine-1-carboxylate
CAS No.	1259011-99-8
Molecular Formula	C11H20F2N2O2
Molecular Weight	250.29 g/mol
Synonyms	1-Boc-2-(aminomethyl)-4,4-difluoropiperidine; 1-(tert-Butoxycarbonyl)-2-(aminomethyl)-4,4-difluoropiperidine; 4,4-Difluoro-2-(aminomethyl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 2-(aminomethyl)-4,4-difluoro-1-piperidinecarboxylate; 2-(Aminomethyl)-4,4-difluoropiperidine-1-carboxylic acid tert-butyl ester; N-Boc-2-(aminomethyl)-4,4-difluoropiperidine; Boc-2-(Aminomethyl)-4,4-difluoropiperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(Aminomethyl)-4,4-difluoropiperidine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.