Description

Ly2940680 is a potent and selective small-molecule inhibitor of the Hedgehog (Hh) signaling pathway, specifically targeting the Smoothened (SMO) receptor. This compound is a critical research tool for investigating the role of aberrant Hh pathway activation in various cancers and developmental disorders. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, regenerative medicine, and molecular biology.

Application

• Oncology Research: Used in preclinical studies to investigate the role of Hedgehog signaling in cancers such as basal cell carcinoma, medulloblastoma, pancreatic cancer, and leukemia.
• Drug Discovery & Development: Serves as a reference standard and pharmacological tool in high-throughput screening and lead optimization programs targeting the SMO receptor.
• Mechanistic Studies: Enables the study of cellular proliferation, differentiation, and stem cell maintenance pathways regulated by Hedgehog signaling.
• Biochemical Assays: Employed in cell-based and biochemical assays to validate SMO inhibitor activity and assess pathway inhibition efficacy.
• Academic Research: Supports fundamental research in developmental biology, tissue regeneration, and disease modeling.

Basic Information

Product Name	Ly2940680
CAS No.	1258861-20-9
Molecular Formula	C₂₆H₂₈F₃N₅O₂
Molecular Weight	499.53 g/mol
Synonyms	LY2940680; Taladegib; LY-2940680; 5-Chloro-N2-[1-(4-fluorophenyl)ethyl]-N4-[4-morpholinyl-2-(1H-pyrazol-4-yl)-4-pyrimidinyl]-2,4-pyrimidinediamine; UNII-9Q6Q6SGD31; 5-Chloro-N2-[1-(4-fluorophenyl)ethyl]-N4-[4-morpholin-4-yl-2-(1H-pyrazol-4-yl)pyrimidin-4-yl]pyrimidine-2,4-diamine
EINECS	Contact for details

Quality Control

Our Ly2940680 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert conditions for long-term stability. Allow the product to equilibrate to room temperature in a dry environment before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.