Description

5-(2-Chloro-4-Methylphenyl)Pyridin-2-Amine is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1258634-27-3. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), valued for its specific halogenated aromatic and heterocyclic structure. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new therapeutic and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drugs, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Serves as a core scaffold for developing new-generation herbicides and fungicides with specific modes of action.
• Chemical Synthesis Building Block: Used in organic synthesis for constructing complex molecules containing pyridine and chlorinated phenyl motifs.
• Material Science Research: Investigated as a monomer or ligand for creating specialized polymers and metal-organic frameworks (MOFs).
• Academic & R&D Laboratories: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	5-(2-Chloro-4-Methylphenyl)Pyridin-2-Amine
CAS No.	1258634-27-3
Molecular Formula	C12H11ClN2
Molecular Weight	218.68 g/mol
Synonyms	2-Amino-5-(2-chloro-4-methylphenyl)pyridine; 5-(2-Chloro-p-tolyl)pyridin-2-amine; 2-Pyridinamine, 5-(2-chloro-4-methylphenyl)-; 1258634-27-3; 5-(2-Chloro-4-methylphenyl)-2-pyridinamine; 5-(2-Chloro-4-methylphenyl)-2-aminopyridine
EINECS	Contact for details

Quality Control

Every batch of 5-(2-Chloro-4-Methylphenyl)Pyridin-2-Amine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (HPLC), residual solvents, and related substances. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the original container tightly sealed to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.