Description

3-(3-(Trifluoromethoxy)Phenyl)Pyridin-4-Amine is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethoxy-substituted aromatic structure. This compound is critical for medicinal chemistry research and development, offering a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorinated motifs for enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Research: Used in the development of new pesticides and herbicides where the trifluoromethoxy group can improve lipophilicity and biological activity.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of advanced polymers and organic electronic materials.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research exploring the effects of fluorinated aromatic systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke molecules for client-specific projects.

Basic Information

Product Name	3-(3-(Trifluoromethoxy)Phenyl)Pyridin-4-Amine
CAS No.	1258608-56-8
Molecular Formula	C12H9F3N2O
Molecular Weight	254.21 g/mol
Synonyms	4-Amino-3-[3-(trifluoromethoxy)phenyl]pyridine; 3-(3-(Trifluoromethoxy)phenyl)-4-pyridinamine; 4-Pyridinamine, 3-[3-(trifluoromethoxy)phenyl]-; 3-(3-Trifluoromethoxyphenyl)pyridin-4-amine; 3-(3-(Trifluoromethoxy)phenyl)-4-aminopyridine
EINECS	Contact for details

Quality Control

Our 3-(3-(Trifluoromethoxy)Phenyl)Pyridin-4-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its sensitivity, the container should be kept under an inert atmosphere (e.g., nitrogen) to prevent oxidation and moisture absorption. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.