Description

Azd-5582 CAS NO 1258392-53-8 is a potent and selective small molecule inhibitor of the IAP (Inhibitor of Apoptosis Protein) family, specifically targeting cIAP1 and XIAP. This compound is of significant value for its role in inducing apoptosis in cancer cells and is a critical research tool for studying programmed cell death pathways. It is primarily needed by pharmaceutical R&D departments, academic research institutions, and biotechnology companies engaged in oncology drug discovery and preclinical studies.

Application

• Oncology Research: A key tool compound for investigating apoptosis mechanisms and evaluating the therapeutic potential of IAP inhibition in various cancer cell lines.
• Drug Discovery & Development: Used as a reference standard and a lead compound in the development of novel anti-cancer therapeutics targeting the IAP family.
• Biochemical Assays: Employed in high-throughput screening (HTS) and in vitro assays to study protein-protein interactions and caspase activation.
• Preclinical Studies: Utilized in animal models to evaluate the efficacy, pharmacokinetics, and pharmacodynamics of IAP-targeted therapies.
• Signal Pathway Analysis: Essential for research into the NF-κB signaling pathway and its role in cell survival, inflammation, and immune response.
• Combination Therapy Research: Investigated for its synergistic effects when used alongside other chemotherapeutic agents or radiation therapy.

Basic Information

Product Name	Azd-5582
CAS No.	1258392-53-8
Molecular Formula	C₂₉H₃₀N₈O₃
Molecular Weight	538.60 g/mol
Synonyms	AZD5582; AZD-5582; 2-[(3S)-3-[[4-(7-Methoxyquinolin-4-yl)oxyphenyl]methyl]-4-oxo-5-(2-phenylethynyl)-1,3-thiazolidin-2-ylidene]-2-cyano-N-methylacetamide; (3S)-3-[[4-[(7-Methoxy-4-quinolinyl)oxy]phenyl]methyl]-4-oxo-5-(2-phenylethynyl)-2-[(2Z)-2-cyano-2-(methylcarbamoyl)ethylidene]-1,3-thiazolidine; cIAP1/XIAP Inhibitor
EINECS	Contact for details

Quality Control

Every batch of Azd-5582 is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are suitable for research and development use, with specifications typically meeting or exceeding 95% purity by HPLC. Certificates of Analysis (COA) detailing batch-specific results for assay, impurities, and identification are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert conditions for long-term stability. For short-term storage, keep the product at 2-8°C in a dry environment. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.