Description

1H-Pyrazole, 1-[trans-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]cyclohexyl]-4-iodo- is a high-value, organosilicon-protected pyrazole derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in providing a versatile, functionalized scaffold for constructing complex molecules, particularly in pharmaceutical discovery and materials science. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise building blocks for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly for targeted therapies.
• Agrochemical Research: Used in the development of new pesticides and herbicides due to the bioactive pyrazole core.
• Ligand Synthesis: Serves as a precursor for creating specialized ligands in catalysis and coordination chemistry.
• Material Science: Intermediate in the synthesis of organic electronic materials and advanced polymers.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Chemical Biology Probes: Used to create labeled compounds or probes for studying biological systems and mechanisms.

Basic Information

Product Name	1H-Pyrazole, 1-[trans-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]cyclohexyl]-4-iodo-
CAS No.	1257997-18-4
Molecular Formula	C15H27IN2OSi
Molecular Weight	406.38 g/mol
Synonyms	1-((1r,4r)-4-((tert-Butyldimethylsilyl)oxy)cyclohexyl)-4-iodo-1H-pyrazole; 4-Iodo-1-[trans-4-(tert-butyldimethylsilyloxy)cyclohexyl]pyrazole; trans-4-(4-Iodo-1H-pyrazol-1-yl)cyclohexyl tert-butyldimethylsilyl ether; 1-(trans-4-((tert-Butyldimethylsilyl)oxy)cyclohexyl)-4-iodo-1H-pyrazole; TBS-protected 4-iodopyrazole cyclohexyl ether
EINECS	Contact for details

Quality Control

Every batch of 1H-Pyrazole, 1-[trans-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]cyclohexyl]-4-iodo- is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes results from HPLC, NMR, and other relevant spectroscopic methods. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.