Description

1-tert-Butyl 3-Methyl 4-(2-Chloro-4-Iodopyridin-3-Yl)Pyrrolidine-1,3-Dicarboxylate is a high-purity, multi-functional heterocyclic building block designed for advanced pharmaceutical and agrochemical research. This compound is a critical intermediate in the synthesis of complex molecules, offering a unique scaffold for medicinal chemistry and drug discovery programs. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and crop protection industries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization due to its substituted pyridine and pyrrolidine motifs.
• Agrochemical Synthesis: Intermediate in the development of new generation herbicides, fungicides, and insecticides with enhanced efficacy.
• Chemical Biology Probes: Used in the design and synthesis of molecular probes for studying biological pathways and target validation.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and cGMP manufacturing of clinical trial materials.
• Contract Research & Manufacturing (CRO/CMO): Essential raw material for custom synthesis and development services.

Basic Information

Product Name	1-tert-Butyl 3-Methyl 4-(2-Chloro-4-Iodopyridin-3-Yl)Pyrrolidine-1,3-Dicarboxylate
CAS No.	1257850-08-0
Molecular Formula	C16H20ClIN2O4
Molecular Weight	466.70 g/mol
Synonyms	1-(tert-Butyl) 3-Methyl 4-(2-chloro-4-iodopyridin-3-yl)pyrrolidine-1,3-dicarboxylate; 4-(2-Chloro-4-iodopyridin-3-yl)-1,3-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 3-methyl ester; 1-Boc-3-methyl 4-(2-chloro-4-iodo-3-pyridyl)pyrrolidine-1,3-dicarboxylate; tert-Butyl methyl 4-(2-chloro-4-iodopyridin-3-yl)pyrrolidine-1,3-dicarboxylate; Pyrrolidine-1,3-dicarboxylic acid, 4-(2-chloro-4-iodo-3-pyridinyl)-, 1-(1,1-dimethylethyl) 3-methyl ester
EINECS	Contact for details

Quality Control

Every batch of 1-tert-Butyl 3-Methyl 4-(2-Chloro-4-Iodopyridin-3-Yl)Pyrrolidine-1,3-Dicarboxylate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up applications. Certificates of Analysis (COA) with full analytical data are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.