Description

tert-Butyl 3-(4-Fluoro-1-Piperidyl)Azetidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique azetidine-piperidine hybrid scaffold. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) engaged in drug discovery programs targeting central nervous system (CNS) disorders, oncology, and inflammation.

Application

• Key Intermediate in Drug Discovery: Serves as a critical building block for the synthesis of potential drug candidates, especially those requiring a constrained azetidine ring system.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to modulate pharmacokinetic properties like solubility and metabolic stability.
• Proteolysis Targeting Chimera (PROTAC) Development: Its structure can be utilized in the linker or ligand components of PROTAC molecules for targeted protein degradation.
• CNS-Active Compound Synthesis: The fluorinated piperidine moiety makes it relevant for developing compounds intended to cross the blood-brain barrier.
• Library Synthesis for High-Throughput Screening: Employed to create focused chemical libraries for biological screening against various therapeutic targets.
• Process Chemistry & Scale-Up: Used in route scouting and process development for the commercial-scale manufacture of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	tert-Butyl 3-(4-Fluoro-1-Piperidyl)Azetidine-1-Carboxylate
CAS No.	1257293-82-5
Molecular Formula	C13H23FN2O2
Molecular Weight	258.34 g/mol
Synonyms	1-Boc-3-(4-Fluoropiperidin-1-yl)azetidine; tert-Butyl 3-(4-fluoropiperidin-1-yl)azetidine-1-carboxylate; 3-(4-Fluoro-1-piperidinyl)-1-azetidinecarboxylic acid 1,1-dimethylethyl ester; 1-(1-(tert-Butoxycarbonyl)azetidin-3-yl)-4-fluoropiperidine; Azetidine-1-carboxylic acid, 3-(4-fluoro-1-piperidinyl)-, 1,1-dimethylethyl ester; 3-(4-Fluoropiperidino)azetidine-1-carboxylic acid tert-butyl ester; 1-Boc-3-(4-fluoro-piperidin-1-yl)-azetidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(4-Fluoro-1-Piperidyl)Azetidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring suitability for use in advanced pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.