Description

5-Hydroxymethyl-2’-Deoxycytidine Cyclic Carbamate is a chemically modified nucleoside derivative, serving as a key intermediate in advanced oligonucleotide synthesis. This compound is critical for the development of therapeutic nucleic acids, enabling precise modifications that enhance stability and efficacy. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers specializing in antisense oligonucleotides, siRNA, and other cutting-edge genetic medicines.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of modified oligonucleotides used in therapeutic applications.
• Antisense Oligonucleotide (ASO) Development: Enables the incorporation of stabilizing modifications to improve drug-like properties.
• siRNA and miRNA Synthesis: Used in the production of RNA-based therapeutics for targeted gene silencing.
• Research and Development: Serves as a valuable tool in academic and industrial labs for studying nucleic acid chemistry and biology.
• Diagnostic Probe Synthesis: Can be utilized in creating labeled probes for genetic testing and molecular diagnostics.
• Precision Medicine: Supports the development of personalized therapies that require specific nucleotide modifications.

Basic Information

Item	Detail
Product Name	5-Hydroxymethyl-2’-Deoxycytidine Cyclic Carbamate
CAS No.	1257247-41-8
Molecular Formula	C11H14N4O6
Molecular Weight	298.25 g/mol
Synonyms	5-HydroxymethyldC-Carbamate; 5-HMdC-Carbamate; 5-Hydroxymethyl-2'-deoxycytidine 5,6-cyclic carbamate; 2'-Deoxy-5-hydroxymethylcytidine cyclic carbamate; 5-Hydroxymethyl-dC cyclic carbamate; 5-(Hydroxymethyl)-2'-deoxycytidine cyclic carbamate; 5-Hydroxymethylcytosine derivative (cyclic carbamate); 5-HMdC cyclic carbamate
EINECS	Contact for details

Quality Control

Our production of 5-Hydroxymethyl-2’-Deoxycytidine Cyclic Carbamate adheres to stringent quality protocols suitable for pharmaceutical intermediate applications. Each batch is characterized and tested to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles via validated analytical methods such as HPLC, NMR, and MS. Our quality system is designed to support GMP-compliant workflows for critical therapeutic development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under a dry, inert atmosphere to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.