Description

Abt-199 CAS NO 1257044-40-8 is a potent and selective small molecule inhibitor of B-cell lymphoma 2 (BCL-2), a key anti-apoptotic protein. This compound is of significant value in pharmaceutical research and development for targeting apoptosis pathways dysregulated in various cancers. It is primarily needed by researchers and manufacturers in the oncology, biochemistry, and pharmaceutical sectors for drug discovery, preclinical studies, and as a reference standard.

Application

• Oncology Research: As a critical tool compound for studying BCL-2 mediated apoptosis and resistance mechanisms in hematological and solid tumor models.
• Drug Discovery & Development: Serving as a lead compound or pharmacophore for the design and synthesis of novel BCL-2 inhibitor therapeutics.
• Biochemical Assays: Used in high-throughput screening (HTS), binding assays, and enzymatic studies to evaluate BCL-2 family protein interactions.
• Preclinical Studies: Employed in in vitro and in vivo studies to assess efficacy, pharmacokinetics, and toxicology profiles.
• Reference Standard: Utilized as an analytical standard for quality control and method validation in pharmaceutical manufacturing.
• Mechanistic Biology: A key reagent for investigating programmed cell death and developing combination therapies.

Basic Information

Product Name	Abt-199
CAS No.	1257044-40-8
Molecular Formula	C45H50ClN7O7S
Molecular Weight	868.44 g/mol
Synonyms	Venetoclax; ABT-199; GDC-0199; RG7601; 4-[4-[[2-(4-Chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl]sulfonyl-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
EINECS	Contact for details

Quality Control

Our Abt-199 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided to support research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. For long-term storage, consider under an inert atmosphere. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.