Description

4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-Tosyl-1,2,3,6-Tetrahydropyridine is a high-value, protected boronic ester derivative that serves as a critical synthetic intermediate. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing carbon-carbon bonds in complex molecule synthesis. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the efficient production of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, particularly in creating biaryl and heterobiaryl motifs prevalent in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific aryl-aryl linkages.
• Material Science Research: Employed in the construction of organic electronic materials, such as those for OLEDs and organic photovoltaics, where precise molecular architecture is crucial.
• Chemical Biology & Probe Development: Serves as a versatile handle for introducing the tetrahydropyridine-tosyl moiety into larger biomolecules or chemical probes for biological target engagement studies.
• Catalyst & Ligand Preparation: Useful in the synthesis of novel nitrogen-containing ligands or organocatalysts for asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-Tosyl-1,2,3,6-Tetrahydropyridine
CAS No.	1256360-46-9
Molecular Formula	C18H26BNO4S
Molecular Weight	363.28 g/mol
Synonyms	1-Tosyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(4-methylphenyl)sulfonyl-1,2,3,6-tetrahydropyridine; 1,2,3,6-Tetrahydro-1-tosyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1,2,3,6-tetrahydropyridine; 4-Pinacolatoboryl-1-tosyl-1,2,3,6-tetrahydropyridine; N-Tosyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict in-process controls and final release testing to ensure batch-to-batch consistency and reliability for your synthetic workflows. Quality is verified via modern analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended long-term storage at 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.