Description

(4-Bromo-3,5-Difluorophenyl)Methanol is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its core value lies in the strategic placement of bromine and fluorine substituents, which enable precise functionalization and serve as key handles for cross-coupling reactions in complex molecule construction. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and specialty polymers.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated aromatic cores in advanced electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromine atom acts as an excellent site for Suzuki, Stille, and Buchwald-Hartwig amination reactions to form complex biaryl structures.
• Ligand & Catalyst Development: Utilized in the preparation of specialized phosphine or nitrogen-based ligands for asymmetric catalysis.
• Polymer Modification: Incorporated into polymer backbones to impart specific properties like chemical resistance, thermal stability, or altered solubility.
• Chemical Biology Probes: Used in the development of fluorinated probes and tags for imaging and diagnostic applications.

Basic Information

Product Name	(4-Bromo-3,5-Difluorophenyl)Methanol
CAS No.	1256276-36-4
Molecular Formula	C7H5BrF2O
Molecular Weight	223.02 g/mol
Synonyms	4-Bromo-3,5-difluorobenzyl alcohol; (4-Bromo-3,5-difluorophenyl)methanol; 3,5-Difluoro-4-bromobenzyl alcohol; 1-(Bromomethyl)-3,5-difluorobenzene-4-ol; α-Hydroxymethyl-4-bromo-3,5-difluorobenzene; 4-Bromo-α,3,5-trifluorobenzyl alcohol; Benzenemethanol, 4-bromo-3,5-difluoro-
EINECS	Contact for details

Quality Control

Our (4-Bromo-3,5-Difluorophenyl)Methanol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is sensitive to strong alkalis and fluorides; keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.