Description

5,5-Difluoropiperidin-2-One is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic incorporation of two fluorine atoms on the piperidine ring, which can dramatically influence the metabolic stability, lipophilicity, and binding affinity of target molecules. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the design and synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for constructing fluorinated piperidine scaffolds present in central nervous system (CNS) drugs, enzyme inhibitors, and receptor modulators.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides where fluorine atoms enhance biological activity and environmental persistence.
• Medicinal Chemistry: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead optimization programs.
• Fluorine Chemistry: An important reagent for exploring novel fluorination reactions and synthesizing complex fluorinated compounds for material science.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and process development for global clients.

Basic Information

Item	Details
Product Name	5,5-Difluoropiperidin-2-One
CAS No.	1255666-50-2
Molecular Formula	C5H7F2NO
Molecular Weight	135.11 g/mol
Synonyms	5,5-Difluoro-2-piperidone; 5,5-Difluoropiperidin-2-one; 2-Piperidinone, 5,5-difluoro-; 5,5-Difluoro-1,2,3,6-tetrahydropyridin-2-one; 5,5-Difluoro-2-oxopiperidine; 5,5-Difluoropiperidinone; 5,5-Difluoro-2-piperidinone; 5,5-Difluoro-dihydro-2(1H)-pyridinone
EINECS	Contact for details

Quality Control

Every batch of 5,5-Difluoropiperidin-2-One is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.