Description

1-Piperidinecarboxylic Acid, 4-Amino-3,3-Difluoro-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluorinated piperidine scaffold. This compound is of significant commercial importance for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modification. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new drugs, agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially for protease inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides where the difluoro-amino piperidine moiety can enhance biological activity and stability.
• Chemical Research & Development: Serves as a versatile building block for medicinal chemists exploring structure-activity relationships (SAR) and novel chemical entities.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals for various industrial applications.
• Bioconjugation & Ligand Synthesis: The amino and ester functional groups make it suitable for constructing ligands, linkers, and probes used in biochemical and diagnostic applications.

Basic Information

Product Name	1-Piperidinecarboxylic Acid, 4-Amino-3,3-Difluoro-, 1,1-Dimethylethyl Ester
CAS No.	1255666-48-8
Molecular Formula	C10H18F2N2O2
Molecular Weight	236.26 g/mol
Synonyms	tert-Butyl 4-amino-3,3-difluoropiperidine-1-carboxylate; 4-Amino-3,3-difluoropiperidine-1-carboxylic acid tert-butyl ester; 3,3-Difluoro-4-aminopiperidine-1-carboxylic acid tert-butyl ester; Boc-4-amino-3,3-difluoropiperidine; N-Boc-4-amino-3,3-difluoropiperidine; 4-Amino-3,3-difluoro-1-N-Boc-piperidine; 1-Boc-4-amino-3,3-difluoropiperidine; 4-Amino-3,3-difluoropiperidine hydrochloride tert-butyl carbamate (related salt form)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. Each batch is controlled via modern analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for assay, impurities, and other critical parameters are available upon request. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.