Description

p-[[(1S)-2-(6-Amino-9H-Purin-9-Yl)-1-Methylethoxy]Methyl]-Phosphonic Acid Monoethyl Ester is a high-purity, chiral nucleoside phosphonate derivative, a critical building block in advanced pharmaceutical research and development. Its primary value lies in its role as a key synthetic intermediate for novel antiviral and anticancer prodrugs, enabling the targeted delivery of active nucleotide analogs. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on developing next-generation therapeutics, particularly for viral infections and oncology applications.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of nucleotide analog prodrugs, such as those targeting viral polymerases.
• Antiviral Drug Development: Used in R&D for novel therapeutics against hepatitis B (HBV), hepatitis C (HCV), and other viral diseases.
• Anticancer Agent Synthesis: Serves as a building block for creating nucleoside-based chemotherapeutic agents.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate nucleotide metabolism pathways.
• Prodrug Design: Utilized to enhance the bioavailability and cellular uptake of poorly permeable nucleotide drugs through phosphonate masking strategies.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs developing client-specific active pharmaceutical ingredients (APIs).

Basic Information

Product Name	p-[[(1S)-2-(6-Amino-9H-Purin-9-Yl)-1-Methylethoxy]Methyl]-Phosphonic Acid Monoethyl Ester
CAS No.	1255525-18-8
Molecular Formula	C₁₂H₁₈N₅O₅P
Molecular Weight	343.28 g/mol
Synonyms	(S)-9-[2-[[(Ethoxy(hydroxy)phosphoryl)methoxy]methyl]propyl]adenine; (1S)-2-(6-Amino-9H-purin-9-yl)-1-methylethyl methanephosphonate monoethyl ester; Adenine phosphonate monoethyl ester derivative; GS-7340 intermediate; Tenofovir alafenamide (TAF) related intermediate; (S)-HPMPA monoethyl ester analog; Nucleoside phosphonate prodrug intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of p-[[(1S)-2-(6-Amino-9H-Purin-9-Yl)-1-Methylethoxy]Methyl]-Phosphonic Acid Monoethyl Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. Production can be aligned with cGMP guidelines for advanced applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in a desiccator for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.