Description

1H-Pyrrolo[3,2-B]Pyridine-1-Carboxylic Acid, 2,3-Dihydro-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused heterocyclic structure. This compound is critical for research and development in medicinal chemistry, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) focused on developing new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates and novel small molecule therapeutics.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Integral to the production route of target Active Pharmaceutical Ingredients (APIs), especially those containing fused pyrrolopyridine motifs.
• Contract Manufacturing (CDMO): Supplied to Contract Development and Manufacturing Organizations for scale-up and cGMP production of clinical trial materials.
• Academic & Institutional Research: Employed in university and institutional labs for fundamental research in heterocyclic chemistry and new synthetic methodology development.
• Proteolysis Targeting Chimera (PROTAC) Development: Potential use as a component in the linker or warhead design for targeted protein degradation therapeutics.

Basic Information

Product Name	1H-Pyrrolo[3,2-B]Pyridine-1-Carboxylic Acid, 2,3-Dihydro-, 1,1-Dimethylethyl Ester
CAS No.	1254360-67-2
Molecular Formula	C13H16N2O2
Molecular Weight	232.28 g/mol
Synonyms	tert-Butyl 2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-1-carboxylate; 1-Boc-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine; 1H-Pyrrolo[3,2-b]pyridine-1-carboxylic acid, 2,3-dihydro-, 1,1-dimethylethyl ester; 2,3-Dihydro-1H-pyrrolo[3,2-b]pyridine-1-carboxylic acid tert-butyl ester; Boc-2,3-dihydropyrrolo[3,2-b]pyridine; 1-N-Boc-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrolo[3,2-B]Pyridine-1-Carboxylic Acid, 2,3-Dihydro-, 1,1-Dimethylethyl Ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, and our quality systems support development under cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.