Description

N3-Aeea-Aeea CAS NO 1254054-60-8 is a specialized bifunctional linker molecule containing azide and amine-reactive groups, designed for advanced bioconjugation and click chemistry applications. This compound is critical for creating stable, site-specific linkages between biomolecules, polymers, and surfaces, enabling precise control in complex material assembly. It is essential for researchers and manufacturers in the pharmaceutical, diagnostics, and advanced materials sectors who require high-purity, reliable building blocks for developing novel therapeutics, biosensors, and functionalized nanomaterials.

Application

• Bioconjugation Reagent: For the site-specific labeling and cross-linking of proteins, antibodies, peptides, and oligonucleotides.
• Click Chemistry Synthesis: As a key intermediate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC) reactions.
• Polymer Functionalization: To introduce reactive azide groups onto polymer backbones for subsequent modification and creation of smart materials.
• Surface Immobilization: For the covalent attachment of biomolecules to chips, beads, and other solid supports used in biosensing and diagnostic platforms.
• Antibody-Drug Conjugate (ADC) Development: As a linker in the synthesis of next-generation ADCs, connecting cytotoxic payloads to targeting antibodies.
• Hydrogel and Biomaterial Fabrication: Enabling the formation of cross-linked networks with tailored biological functionality for tissue engineering and drug delivery systems.

Basic Information

Product Name	N3-Aeea-Aeea
CAS No.	1254054-60-8
Molecular Formula	C10H20N6O4
Molecular Weight	288.31 g/mol
Synonyms	1-Azido-3,6,9,12-tetraoxapentadecan-15-oic acid 2,5-dioxopyrrolidin-1-yl ester; 15-Azido-4,7,10,13-tetraoxapentadecanoic acid N-hydroxysuccinimide ester; Azido-PEG4-NHS ester; N3-PEG4-NHS ester; NHS-PEG4-Azide; Azido-PEG4-NHS ester; Azido tetraethyleneglycol NHS ester
EINECS	Contact for details

Quality Control

Our N3-Aeea-Aeea is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive research and production applications. Each lot is characterized by multiple analytical techniques, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is moisture-sensitive and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.