Description

Methanone, [4-(Difluoromethoxy)-3-[2-(2-Pyridinyl)Ethynyl]Phenyl](5,7-Dihydro-6H-Pyrrolo[3,4-B]Pyridin-6-Yl)-, Hydrochloride (1:1) is a high-purity, non-racemic pharmaceutical intermediate and research chemical. This compound is of significant value for its role as a key building block in the synthesis of complex, biologically active molecules, particularly in medicinal chemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, especially within kinase inhibitor programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of advanced drug candidates, particularly for targeted therapies.
• Kinase Inhibitor Research: Serves as a core scaffold or a functionalized fragment in the design and discovery of novel protein kinase inhibitors.
• Medicinal Chemistry & SAR Studies: Used to explore structure-activity relationships (SAR) by introducing specific substitutions to optimize potency and selectivity.
• Biochemical Assay Development: Employed as a reference standard or a probe compound in high-throughput screening (HTS) and in vitro biological assays.
• Process Chemistry & Scale-Up: Supports route scouting and optimization for the efficient, large-scale production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and chemical biology.

Basic Information

Product Name	Methanone, [4-(Difluoromethoxy)-3-[2-(2-Pyridinyl)Ethynyl]Phenyl](5,7-Dihydro-6H-Pyrrolo[3,4-B]Pyridin-6-Yl)-, Hydrochloride (1:1)
CAS No.	1253291-28-9
Molecular Formula	C23H16F2N3O2 · HCl
Molecular Weight	455.85 g/mol (Free base: 419.39 g/mol)
Synonyms	[4-(Difluoromethoxy)-3-[2-(pyridin-2-yl)ethynyl]phenyl](5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)methanone hydrochloride; (5,7-Dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)(4-(difluoromethoxy)-3-((pyridin-2-yl)ethynyl)phenyl)methanone hydrochloride; 6-[4-(Difluoromethoxy)-3-(2-pyridin-2-ylethynyl)benzoyl]-5,7-dihydro-6H-pyrrolo[3,4-b]pyridine hydrochloride; CAS 1253291-28-9; BMS Intermediate (related to kinase inhibitor research); Kinase Inhibitor Fragment; Heterocyclic Methanone Hydrochloride Salt
EINECS	Contact for details

Quality Control

Our Methanone, [4-(Difluoromethoxy)-3-[2-(2-Pyridinyl)Ethynyl]Phenyl](5,7-Dihydro-6H-Pyrrolo[3,4-B]Pyridin-6-Yl)-, Hydrochloride (1:1) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing specific results are available upon request. We adhere to cGMP principles where applicable to support pre-clinical and clinical supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 97.0% (Area Percent)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.