Description

2'-o-(2-Methoxyethyl)-5-Iodouridine is a modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key intermediate in the synthesis of oligonucleotides, particularly for antisense and siRNA therapeutic applications. It is primarily utilized by research institutions, pharmaceutical companies, and CROs engaged in the development of novel nucleic acid-based drugs and diagnostic probes.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A critical building block for constructing modified oligonucleotides designed for gene silencing and therapeutic modulation of gene expression.
• siRNA (Small Interfering RNA) Production: Used in the manufacture of stabilized siRNA molecules to enhance nuclease resistance and improve pharmacokinetic properties for RNA interference (RNAi) therapies.
• Pharmaceutical Intermediate: Serves as a high-purity intermediate in the multi-step synthesis of active pharmaceutical ingredients (APIs) for experimental and commercial drug formulations.
• Biochemical Research: Employed in academic and industrial laboratories for studying nucleic acid chemistry, enzyme mechanisms, and the structure-activity relationships of modified nucleosides.
• Diagnostic Probe Development: Utilized in the creation of labeled probes for molecular diagnostics, including fluorescence in situ hybridization (FISH) and other detection assays.

Basic Information

Item	Detail
Product Name	2'-o-(2-Methoxyethyl)-5-Iodouridine
CAS No.	1251827-55-0
Molecular Formula	C12H17IN2O7
Molecular Weight	428.18 g/mol
Synonyms	5-Iodo-2'-O-(2-methoxyethyl)uridine; 2'-MOE-5-Iodouridine; 2'-O-(2-Methoxyethyl)-5-iodo-1-β-D-ribofuranosyluracil; 5-Iodo-2'-O-(2-methoxyethyl)uridine; 5-I-2'-MOE-U; 2'-MOE-5-I-Urd; 2'-O-(2-Methoxyethyl)-5-iodouridine; 5-Iodouridine 2'-(2-methoxyethyl) ether
EINECS	Contact for details

Quality Control

Our 2'-o-(2-Methoxyethyl)-5-Iodouridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP guidelines, as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.