Description

1-o-Trimethylsilyl Glycerol Monochlorohydrin is a versatile organosilicon-protected glycerol derivative, serving as a crucial synthetic intermediate. This compound is valued for its role in introducing functionalized glycerol units into more complex molecules under controlled conditions. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as prodrug synthesis and the preparation of phospholipid analogs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of prodrugs, antiviral agents, and other bioactive molecules containing glycerol backbones.
• Lipid & Phospholipid Chemistry: Used in the preparation of synthetic phospholipids, lysophospholipids, and other membrane components for research and diagnostic applications.
• Agrochemical Synthesis: Intermediate in the production of certain herbicides, fungicides, and plant growth regulators that require chlorohydrin or protected polyol motifs.
• Polymer & Material Science: Monomer or cross-linking agent for synthesizing specialty silicones, polyethers, and functional polymers with tailored properties.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules, facilitating studies in chemical biology and medicinal chemistry.
• Organic Synthesis Reagent: Acts as a protected glycidol equivalent or a chiral synthon in asymmetric synthesis for constructing complex natural products.

Basic Information

Product Name	1-o-Trimethylsilyl Glycerol Monochlorohydrin
CAS No.	1246820-26-7
Molecular Formula	C6H15ClO2Si
Molecular Weight	182.72 g/mol
Synonyms	3-Chloro-2-hydroxypropyloxytrimethylsilane; 1-O-(Trimethylsilyl)-3-chloro-1,2-propanediol; 3-Chloro-1-O-trimethylsilyl-1,2-propanediol; Glycerol 1-chlorohydrin 1-O-TMS ether; (3-Chloro-2-hydroxypropoxy)trimethylsilane; TMS-protected glycerol chlorohydrin; Trimethylsilyl 3-chloro-2-hydroxypropyl ether
EINECS	Contact for details

Quality Control

Our 1-o-Trimethylsilyl Glycerol Monochlorohydrin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (HPLC/GC) and spectroscopic methods (NMR, IR), to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Chloride Content	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.