Description

Methyl 2-Methoxy-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinate is a high-value, synthetically versatile boronic ester derivative of a nicotinate scaffold. This compound matters as a critical advanced pharmaceutical intermediate (API) and a key building block in modern organic synthesis, particularly for cross-coupling reactions. It is essential for R&D chemists and manufacturers in the pharmaceutical, agrochemical, and material science industries who require precise molecular construction for novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those containing substituted pyridine or biphenyl motifs via Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require the incorporation of the boronic ester functional group for structural diversification.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or monomers for conjugated polymers.
• Chemical Biology & Proteomics: Employed in the development of chemical probes and activity-based protein profiling (ABPP) agents due to its reactive boronate handle.
• Academic & Industrial R&D: A valuable reagent for methodology development in organic chemistry and for constructing compound libraries for high-throughput screening.

Basic Information

Product Name	Methyl 2-Methoxy-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinate
CAS No.	1246765-27-4
Molecular Formula	C15H22BNO5
Molecular Weight	307.15 g/mol
Synonyms	Methyl 2-Methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carboxylate; 2-Methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinic Acid Methyl Ester; 3-Pyridinecarboxylic acid, 2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; Methyl 6-Bpin-2-methoxynicotinate; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methoxynicotinic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our Methyl 2-Methoxy-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and GC/MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for extended periods to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.