Description

Methyl 1-tert-Butyl-2-Hydroxy-1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylate CAS NO 1246733-24-3 is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyrrolopyridine core structure. This compound is of significant value for its role as a critical building block in the synthesis of novel, complex active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within oncology and other specialized drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of complex drug candidates, especially those targeting protein kinases and other enzymatic pathways.
• Oncology Research: Used in the research and development of novel anti-cancer agents due to the biological relevance of the pyrrolopyridine scaffold.
• Chemical Synthesis Building Block: Provides a functionalized heterocyclic core for further derivatization and structure-activity relationship (SAR) studies in medicinal chemistry.
• Process Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Research & Manufacturing (CRAM): Supplied to organizations providing custom synthesis and process optimization services for the pharmaceutical industry.

Basic Information

Product Name	Methyl 1-tert-Butyl-2-Hydroxy-1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylate
CAS No.	1246733-24-3
Molecular Formula	C13H16N2O3
Molecular Weight	248.28 g/mol
Synonyms	1-(tert-Butyl)-2-hydroxy-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester; Methyl 1-(tert-butyl)-2-hydroxy-1H-pyrrolo[2,3-b]pyridine-3-carboxylate; 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 1-(1,1-dimethylethyl)-2-hydroxy-, methyl ester; 1246733-24-3; Pyrrolopyridine derivative intermediate
EINECS	Contact for details

Quality Control

Our production of Methyl 1-tert-Butyl-2-Hydroxy-1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and purity suitable for pharmaceutical research. All materials are characterized and tested using advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to preserve stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 1.0%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.