Description

Azd 7762 Hydrochloride is a potent and selective small molecule inhibitor of the checkpoint kinase Chk1, which plays a critical role in the DNA damage response pathway. This compound is a valuable research-grade chemical for investigating cell cycle regulation, DNA repair mechanisms, and potential therapeutic strategies in oncology. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on cancer biology and drug discovery.

Application

• Biochemical Research: Used as a key pharmacological tool to study the Chk1 signaling pathway and its role in the DNA damage checkpoint.
• Cancer Research: Investigated for its potential to sensitize cancer cells to DNA-damaging chemotherapeutic agents by abrogating cell cycle arrest.
• Mechanistic Studies: Employed in vitro and in vivo to understand the mechanisms of cell cycle control, apoptosis, and genomic stability.
• Drug Discovery & Development: Serves as a reference compound or lead structure in the development of novel Chk1 inhibitors for oncology therapeutics.
• Academic Laboratories: A standard reagent for graduate and post-doctoral research projects in molecular biology and pharmacology departments.

Basic Information

Product Name	Azd 7762 Hydrochloride
CAS No.	1246094-78-9
Molecular Formula	C₂₁H₂₀ClN₅O₂ • HCl
Molecular Weight	450.78 g/mol
Synonyms	Azd7762 HCl; AZD-7762 hydrochloride; 3-[(3S)-1-(2-Cyclohexylethyl)pyrrolidin-3-yl]-5-[(Z)-2-phenyl-2H-pyrazol-3-yl]pyrazolo[1,5-a]pyrimidin-7-amine hydrochloride; Chk1 Inhibitor AZD7762; Checkpoint Kinase 1 Inhibitor AZD7762; AZD 7762
EINECS	Contact for details

Quality Control

Our Azd 7762 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.