Description

8-Iodo-[1,2,4]Triazolo[1,5-A]Pyridin-2-Amine is a high-value, heterocyclic organic compound featuring a fused triazolopyridine core functionalized with iodine and an amine group. This unique structure makes it a critical pharmaceutical intermediate and versatile building block for medicinal chemistry research and drug discovery programs. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for constructing novel molecular entities.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Building Block: Used extensively in structure-activity relationship (SAR) studies and lead optimization due to its reactive iodine and amine handles for further derivatization.
• Agrochemical Research: Employed in the development of new active ingredients for crop protection products.
• Chemical Biology Probe Development: Utilized to create tool compounds for studying biological pathways and target validation.
• Material Science Research: Acts as a monomer or functional unit in the development of specialty polymers and organic electronic materials.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl structures.

Basic Information

Item	Detail
Product Name	8-Iodo-[1,2,4]Triazolo[1,5-A]Pyridin-2-Amine
CAS No.	1245648-97-8
Molecular Formula	C6H4IN5
Molecular Weight	273.03 g/mol
Synonyms	8-Iodo-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 8-Iodo-1,2,4-triazolo[1,5-a]pyridin-2-amine; 2-Amino-8-iodo-[1,2,4]triazolo[1,5-a]pyridine; 8-Iodo-2-amino-[1,2,4]triazolo[1,5-a]pyridine; 1245648-97-8; 8-Iodo-1,2,4-triazolo[1,5-a]pyridin-2-ylamine
EINECS	Contact for details

Quality Control

Every batch of 8-Iodo-[1,2,4]Triazolo[1,5-A]Pyridin-2-Amine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical R&D and scale-up processes. Certificates of Analysis (COA) detailing specifications such as HPLC purity, NMR confirmation, and residual solvent levels are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.