Description

2-(5-Bromopyridin-2-Yl)-2,2-Difluoroacetic Acid is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromo and difluoroacetate functional groups, makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Ligand Synthesis: Serves as a starting material for creating sophisticated ligands used in catalysis and material science.
• Fluorinated Building Block: Essential for introducing the difluoroacetic acid moiety into complex organic frameworks in medicinal and materials chemistry.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	2-(5-Bromopyridin-2-Yl)-2,2-Difluoroacetic Acid
CAS No.	1240611-21-5
Molecular Formula	C7H4BrF2NO2
Molecular Weight	252.02 g/mol
Synonyms	2,2-Difluoro-2-(5-bromo-2-pyridinyl)acetic Acid; 5-Bromo-2-pyridyldifluoroacetic Acid; (5-Bromopyridin-2-yl)difluoroacetic Acid; 2-(5-Bromo-2-pyridyl)-2,2-difluoroacetic Acid; α,α-Difluoro-5-bromopicolinic Acid (common name variant); 1240611-21-5; 5-Bromo-2-(difluorocarbonyl)pyridine (related acid chloride precursor)
EINECS	Contact for details

Quality Control

Every batch of 2-(5-Bromopyridin-2-Yl)-2,2-Difluoroacetic Acid is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.