Description

Ixazomib Citrate (Usan) is a citrate salt form of the potent and selective proteasome inhibitor ixazomib, designated as a United States Adopted Name (USAN). This compound is a critical intermediate and active pharmaceutical ingredient (API) in the development and manufacturing of targeted cancer therapeutics. It is primarily required by pharmaceutical R&D laboratories and API manufacturers focused on oncology, particularly for the treatment of multiple myeloma and other hematologic malignancies.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active pharmaceutical ingredient in the formulation of oral anti-cancer medications.
• Oncology Research & Development: A key reference standard and building block in preclinical and clinical research for novel proteasome inhibitor-based therapies.
• Drug Substance Manufacturing: Serves as the final drug substance in the commercial production of finished dosage forms (e.g., capsules).
• Analytical Reference Standard: Used in quality control laboratories for method development, validation, and routine assay testing via HPLC, LC-MS, and NMR.
• Process Chemistry Intermediate: Employed in the synthetic scale-up and optimization of the final ixazomib citrate manufacturing process.
• Biochemical Research: Tool compound for studying proteasome function, protein degradation pathways, and mechanisms of apoptosis in cellular models.

Basic Information

Product Name	Ixazomib Citrate (Usan)
CAS No.	1239908-20-3
Molecular Formula	C₂₀H₂₃BCl₂N₂O₉
Molecular Weight	517.02 g/mol
Synonyms	Ixazomib citrate; MLN9708 citrate; (1R)-1-[[(2S)-3-phenyl-2-[(pyrazinylcarbonyl)amino]propanoyl]amino]-3-methylbutyl]boronic acid citrate; MLN-9708 citrate; Ninlaro™ (brand name) API; Proteasome inhibitor MLN9708 citrate; USAN ixazomib citrate
EINECS	Contact for details

Quality Control

Our Ixazomib Citrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profile. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with relevant standards. We support development and commercial projects requiring material manufactured under current Good Manufacturing Practice (cGMP) guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0% (anhydrous basis)
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity: ≤0.5%; Total impurities: ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.