Description

5-Fluoro-3,4-Dihydro-1,8-Naphthyridin-2(1H)-One is a high-purity, fluorinated naphthyridinone derivative, serving as a critical advanced pharmaceutical intermediate. This compound is valued for its unique heterocyclic structure, which is essential for imparting specific biological activity and metabolic stability in drug molecules. It is primarily required by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly in oncology and antiviral research.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) for investigational drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Oncology Drug Development: Serves as a core scaffold for developing kinase inhibitors and other targeted cancer therapies.
• Antiviral Agent Synthesis: Employed in the research and development of novel antiviral compounds.
• Chemical Biology Probes: Utilized to create molecular probes for studying biological pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and scale-up services.

Basic Information

Product Name	5-Fluoro-3,4-Dihydro-1,8-Naphthyridin-2(1H)-One
CAS No.	1237535-78-2
Molecular Formula	C9H7FN2O
Molecular Weight	178.16 g/mol
Synonyms	5-Fluoro-1,2,3,4-tetrahydro-1,8-naphthyridin-2-one; 5-Fluoro-3,4-dihydro-1H-1,8-naphthyridin-2-one; 5-Fluoro-1,2,3,4-tetrahydro-8-naphthyridin-2-one; 5-Fluoro-1,2,3,4-tetrahydro-1,8-naphthyridin-2(1H)-one; 5-Fluoro-3,4-dihydro-2(1H)-naphthyridinone; 5-Fluoro-1,2,3,4-tetrahydro-8-naphthyridin-2(1H)-one; 5-Fluoro-1,2,3,4-tetrahydro[1,8]naphthyridin-2-one
EINECS	Contact for details

Quality Control

Our 5-Fluoro-3,4-Dihydro-1,8-Naphthyridin-2(1H)-One is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.