Description

4-Nitro-1H-Pyrazolo[3,4-B]Pyridine is a high-purity, advanced pharmaceutical intermediate and heterocyclic building block. This compound is critical for the research and development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and oncology drug discovery programs. It is primarily utilized by pharmaceutical R&D laboratories, agrochemical research facilities, and specialty chemical manufacturers seeking to develop new therapeutic agents and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially kinase inhibitors for oncology and inflammatory diseases.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and pesticides due to its bioactive pyrazolopyridine core.
• Chemical Biology Probe Synthesis: Serves as a precursor for creating molecular probes to study enzyme function and cellular signaling pathways.
• Material Science: A potential precursor for the synthesis of organic electronic materials and ligands for catalytic systems.
• Contract Research & Development (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the life sciences industry.

Basic Information

Product Name	4-Nitro-1H-Pyrazolo[3,4-B]Pyridine
CAS No.	1234616-75-1
Molecular Formula	C6H4N4O2
Molecular Weight	164.12 g/mol
Synonyms	4-Nitro-1H-pyrazolo[3,4-b]pyridine; 1H-Pyrazolo[3,4-b]pyridine, 4-nitro-; 4-Nitro-1H-pyrazolo[3,4-b]pyridin; 4-Nitropyrazolo[3,4-b]pyridine; 4-Nitro-7-azaindazole; 4-Nitro-1H-7-azaindazole; 4-Nitropyrazolopyridine; 1234616-75-1
EINECS	Contact for details

Quality Control

Our 4-Nitro-1H-Pyrazolo[3,4-B]Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and should be handled under an inert atmosphere if prolonged exposure is anticipated. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.