Description

Derazantinib is a potent and selective small-molecule inhibitor targeting fibroblast growth factor receptor (FGFR) kinases. This compound is of significant interest for its role in disrupting key signaling pathways involved in cellular proliferation and survival. It is primarily utilized by pharmaceutical R&D teams and contract manufacturing organizations (CMOs) engaged in the development of targeted cancer therapies and preclinical research.

Application

• Oncology Research: A key investigational agent for studying FGFR-driven tumor models, including urothelial, cholangiocarcinoma, and gastric cancers.
• Pharmaceutical Development: Serves as an active pharmaceutical ingredient (API) or a critical intermediate in the synthesis of novel therapeutic candidates.
• Biochemical Assays: Used as a reference standard or tool compound in high-throughput screening and kinase profiling studies.
• Mechanistic Studies: Facilitates research into drug resistance mechanisms and combination therapy strategies targeting FGFR signaling.

Basic Information

Product Name	Derazantinib
CAS No.	1234356-69-4
Molecular Formula	C₂₃H₂₀FN₅O₂
Molecular Weight	417.44 g/mol
Synonyms	ARQ-087; ARQ087; Derazantinib (INN); (R)-(E)-2-(4-(2-(5-(1-(3,5-Difluorophenyl)ethoxy)-1H-pyrazolo[3,4-b]pyridin-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol; BGJ398 analog; FGFR inhibitor ARQ-087
EINECS	Contact for details

Quality Control

Our Derazantinib is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to current industry standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.