Description

(E)-tert-Butyl 4-(2-(6-(2-(2-(2-Fluoroethoxy)Ethoxy)Ethoxy)Pyridin-3-Yl)Vinyl)Phenyl(Methyl)Carbamate is a sophisticated synthetic intermediate of significant importance in advanced pharmaceutical research and development. Its core value lies in its complex molecular architecture, which incorporates a polyethylene glycol (PEG)-like linker and a fluorinated moiety, making it a critical building block for targeted drug discovery. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutics, particularly in the fields of oncology, targeted drug delivery, and radiopharmaceuticals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex active pharmaceutical ingredients (APIs) for targeted therapies.
• Proteolysis-Targeting Chimera (PROTAC) Development: Used as a linker component to connect E3 ligase ligands with target protein ligands, enabling targeted protein degradation.
• Antibody-Drug Conjugate (ADC) Linker-Payload Synthesis: Serves as a functionalized component for constructing cleavable or non-cleavable linkers in ADC platforms.
• Radiopharmaceutical Precursor: The fluorine atom and PEG chain make it a candidate for developing positron emission tomography (PET) imaging agents or targeted radiotherapeutics.
• Bioconjugation Chemistry: Utilized for attaching small molecules, dyes, or other functional groups to biomolecules like peptides, proteins, or antibodies.
• Chemical Biology Probe Synthesis: Employed in creating molecular tools to study biological pathways and protein function within cells.
• Polymer-Modified Drug Synthesis: Acts as a monomer or modifier to introduce solubility-enhancing PEGylation or specific targeting properties into drug molecules.

Basic Information

Item	Details
Product Name	(E)-tert-Butyl 4-(2-(6-(2-(2-(2-Fluoroethoxy)Ethoxy)Ethoxy)Pyridin-3-Yl)Vinyl)Phenyl(Methyl)Carbamate
CAS No.	1234208-04-8
Molecular Formula	C27H37FN2O6
Molecular Weight	504.60 g/mol
Synonyms	tert-Butyl (E)-4-[2-[6-[2-[2-(2-fluoroethoxy)ethoxy]ethoxy]-3-pyridinyl]ethenyl]-N-methylbenzylcarbamate; (E)-tert-Butyl (4-(2-(6-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)phenyl)(methyl)carbamate; Boc-Protected Amino-PEG3-Fluoride Pyridine Derivative; N-Boc-N-methyl-4-[(E)-2-(6-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}pyridin-3-yl)ethenyl]benzenamine; Fluorinated PEGylated Pyridine Building Block; CAS 1234208-04-8
EINECS	Contact for details

Quality Control

Our (E)-tert-Butyl 4-(2-(6-(2-(2-(2-Fluoroethoxy)Ethoxy)Ethoxy)Pyridin-3-Yl)Vinyl)Phenyl(Methyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.