Description

Prexasertib Mesylate Hydrate is a potent and selective small-molecule inhibitor of the checkpoint kinase CHK1 (Checkpoint kinase 1). This compound is of significant value in oncology research and drug development, as targeting CHK1 is a promising strategy to overcome tumor resistance to DNA-damaging chemotherapies and radiation. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on developing novel cancer therapeutics and studying cell cycle regulation and DNA damage response pathways.

Application

• Oncology Research: Used as a key biochemical tool to study the CHK1 signaling pathway and its role in the DNA damage response (DDR).
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the development of novel CHK1 inhibitors for cancer treatment.
• Combination Therapy Studies: Investigated in preclinical models to enhance the efficacy of genotoxic agents (e.g., chemotherapy, radiotherapy) by abrogating cell cycle checkpoints.
• Biomarker & Mechanism Studies: Utilized to understand mechanisms of resistance and to identify predictive biomarkers for CHK1-targeted therapies.
• Cell Biology & Biochemistry: Applied in in vitro and cellular assays to dissect kinase function and validate target engagement.

Basic Information

Product Name	Prexasertib Mesylate Hydrate
CAS No.	1234015-57-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	LY2606368 Mesylate Hydrate; Prexasertib Methanesulfonate Hydrate; (S)-Prexasertib Mesylate Hydrate; Checkpoint Kinase 1 Inhibitor LY2606368; CHK1 Inhibitor LY2606368 Mesylate; 4-[[(7S)-7-Ethyl-6,7,8,9-tetrahydro-2-(2-morpholin-4-ylethyl)pyrazolo[3,4-h]quinazolin-5-yl]amino]-2-fluorophenol methanesulfonate hydrate
EINECS	Contact for details

Quality Control

Our Prexasertib Mesylate Hydrate is manufactured under strict quality systems suitable for research and development use. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure consistency and reliability. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	Contact for details
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.