Description

Prexasertib Mesylate is a potent and selective small-molecule inhibitor of the checkpoint kinase CHK1. This compound is a critical research tool and pharmaceutical intermediate for developing novel cancer therapeutics, particularly for overcoming resistance to DNA-damaging agents. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and contract research organizations (CROs) focused on oncology drug discovery and preclinical studies.

Application

• Oncology Research & Drug Discovery: A key biochemical tool for studying the DNA damage response (DDR) pathway and CHK1 kinase biology.
• Preclinical Development: Serves as a reference standard and active pharmaceutical ingredient (API) in the formulation of investigational new drugs (INDs).
• Combination Therapy Studies: Used in research to evaluate synergistic effects with chemotherapy or radiotherapy in various cancer cell lines and animal models.
• Biomarker & Mechanism of Action (MoA) Studies: Essential for validating CHK1 as a therapeutic target and understanding resistance mechanisms.
• Pharmaceutical Intermediates: Employed in the synthesis and scale-up of more advanced drug candidates within the CHK1 inhibitor class.

Basic Information

Product Name	Prexasertib Mesylate
CAS No.	1234015-55-4
Molecular Formula	C₂₄H₂₈ClFN₈O₃ • CH₄O₃S
Molecular Weight	603.05 g/mol
Synonyms	LY2606368 Mesylate; (S)-5-((5-Chloro-2-((1-(2-fluoroethyl)piperidin-4-yl)amino)pyrimidin-4-yl)amino)-4-fluoro-1-isopropyl-2-methyl-1H-pyrrole-3-carboxamide methanesulfonate; CHK1 Inhibitor LY2606368; Prexasertib Methanesulfonate; Prexasertib (Mesylate); LY2606368; CHK1/2 Inhibitor II
EINECS	Contact for details

Quality Control

Our Prexasertib Mesylate is manufactured under strict quality systems. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided. We support development activities requiring compliance with cGMP guidelines for API manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	<20 ppm
Assay (HPLC)	95.0% - 105.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.