Description

Abemaciclib Mesylate (LY2835219) is a potent and selective small-molecule inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). This compound matters as a critical active pharmaceutical ingredient (API) and reference standard in oncology research and drug development. It is primarily needed by pharmaceutical manufacturers, biotechnology companies, and contract research organizations (CROs) engaged in the synthesis of targeted cancer therapies and preclinical/clinical studies.

Application

• Active Pharmaceutical Ingredient (API) for the formulation of CDK4/6 inhibitor-based anticancer drugs.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.
• Biochemical Research tool for studying cell cycle regulation, proliferation, and CDK4/6 signaling pathways.
• Preclinical Development for pharmacokinetic, pharmacodynamic, and toxicology studies.
• Oncology Drug Discovery as a lead compound or comparator in screening assays and structure-activity relationship (SAR) studies.

Basic Information

Item	Detail
Product Name	Abemaciclib Mesylate (LY2835219)
CAS No.	1231930-82-7
Molecular Formula	C₂₇H₃₂F₂N₈•CH₄O₃S
Molecular Weight	598.66 g/mol
Synonyms	LY2835219; LY-2835219; Abemaciclib methanesulfonate; N-[5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1H-indol-5-yl]oxy]-2-pyrimidinamine monomethanesulfonate; Verzenio (brand name API); CDK4/6 Inhibitor LY2835219
EINECS	Contact for details

Quality Control

Our Abemaciclib Mesylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting high standards for pharmaceutical intermediates and research chemicals. Certificates of Analysis (COA) with detailed HPLC purity, related substance profiles, and residual solvent data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.