Description

Acrizanib is a potent and selective small molecule inhibitor primarily targeting vascular endothelial growth factor receptor (VEGFR) tyrosine kinases. This compound is of significant interest for its role in disrupting angiogenic signaling pathways, which are critical for tumor growth and metastasis. It is a key research chemical for pharmaceutical R&D teams, medicinal chemists, and biologists focused on developing novel oncology therapeutics and studying cancer biology.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the preclinical development of anti-cancer drugs.
• Kinase Inhibition Studies: Used as a selective VEGFR inhibitor in biochemical and cellular assays to study angiogenesis and related signaling cascades.
• In-vitro & In-vivo Pharmacology: Employed in laboratory research to evaluate efficacy, pharmacokinetics, and mechanism of action in various cancer models.
• Medicinal Chemistry Optimization: Provides a core scaffold for the synthesis and structure-activity relationship (SAR) study of novel VEGFR-targeting analogs.
• High-Throughput Screening (HTS): Utilized as a control compound in screening campaigns to identify new anti-angiogenic agents.

Basic Information

Product Name	Acrizanib
CAS No.	1229453-99-9
Molecular Formula	C₂₃H₂₁N₅O₃
Molecular Weight	415.45 g/mol
Synonyms	Acrizanib; 6-[(2,4-Difluorophenyl)methyl]-8-[(3S)-3-hydroxypyrrolidin-1-yl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one; UNII-9K0B0QY3JN; 9K0B0QY3JN; BMS-794833; BMS 794833
EINECS	Contact for details

Quality Control

Every batch of Acrizanib is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay, purity by HPLC, and residual solvents. Our quality commitment aligns with the standards expected for pharmaceutical research materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.