Description

Entospletinib (GS-9973) is a potent, selective, and orally bioavailable inhibitor of spleen tyrosine kinase (SYK), a key signaling molecule in the B-cell receptor pathway. This targeted mechanism makes it a critical compound for research and development in hematological malignancies and autoimmune disorders. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions focused on oncology and immunology.

Application

• Pharmaceutical Research & Development: As a key active pharmaceutical ingredient (API) intermediate or reference standard in the development of novel SYK-targeted therapies.
• Oncology Studies: Preclinical and clinical research for the treatment of B-cell lymphomas, leukemias, and other hematologic cancers where SYK signaling is implicated.
• Autoimmune Disease Research: Investigation into conditions like rheumatoid arthritis, lupus, and allergic asthma, where SYK inhibition can modulate immune response.
• Biochemical Assay Development: Used as a selective tool compound to study SYK kinase activity and signaling pathways in cellular and biochemical assays.
• High-Throughput Screening (HTS): Serves as a control or reference compound in drug discovery screens targeting kinase inhibition.
• Mechanism of Action (MOA) Studies: Fundamental research to elucidate the role of SYK in various disease models and normal physiology.

Basic Information

Item	Details
Product Name	Entospletinib (GS-9973)
CAS No.	1229208-44-9
Molecular Formula	C₂₆H₂₈N₈O₂
Molecular Weight	484.55 g/mol
Synonyms	GS-9973; GS9973; 6-(1H-Indazol-6-yl)-N-[4-(4-methylpiperazin-1-yl)phenyl]imidazo[1,2-a]pyrazin-8-amine; (6-(1H-Indazol-6-yl)-N-(4-(4-methylpiperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine); Entospletinib free base; SYK Inhibitor GS-9973
EINECS	Contact for details

Quality Control

Our Entospletinib (GS-9973) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications are designed to meet the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.