Description

2-Chloro-4-Formylpyridine Hydrate is a versatile pyridine derivative that serves as a critical building block in advanced organic synthesis. Its bifunctional nature, featuring both a reactive aldehyde group and a halogenated heterocyclic ring, makes it an indispensable intermediate for constructing complex molecular architectures. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Ligand and Catalyst Development: Used to prepare chelating ligands for metal catalysts in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Intermediate for synthesizing functional polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Serves as a scaffold for developing molecular probes and fluorescent markers for biological imaging.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and development-scale batches.

Basic Information

Product Name	2-Chloro-4-Formylpyridine Hydrate
CAS No.	1228957-10-5
Molecular Formula	C₆H₄ClNO • xH₂O
Molecular Weight	157.55 (Anhydrous basis)
Synonyms	4-Formyl-2-chloropyridine Hydrate; 2-Chloroisonicotinaldehyde Hydrate; 2-Chloro-4-pyridinecarboxaldehyde Hydrate; 2-Chloro-4-formylpyridine Monohydrate; 2-Chloropyridine-4-carbaldehyde Hydrate; 2-Chloro-4-pyridylcarboxaldehyde Hydrate; 2-Chloroisonicotinaldehyde Monohydrate
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Formylpyridine Hydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for water content, to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized; for long-term storage, consider keeping under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.