Description

1-Pivaloyl-2,3-Dihydro-1H-Pyrido[2,3-B][1,4]-Oxazine-6-Carbonitrile is a high-value, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates, especially within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug molecules, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and novel reaction methodologies.
• Precursor for Bioactive Molecules: Acts as a precursor for molecules with potential pharmacological activity, leveraging its pyrido-oxazine core.

Basic Information

Product Name	1-Pivaloyl-2,3-Dihydro-1H-Pyrido[2,3-B][1,4]-Oxazine-6-Carbonitrile
CAS No.	1228666-61-2
Molecular Formula	C13H15N3O2
Molecular Weight	245.28 g/mol
Synonyms	1-Pivaloyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-6-carbonitrile; 6-Cyano-1-pivaloyl-1,2,3,4-tetrahydropyrido[2,3-b][1,4]oxazine; Tert-butyl 6-cyano-3,4-dihydro-2H-pyrido[2,3-b][1,4]oxazine-1-carboxylate (related structure); Pyrido[2,3-b][1,4]oxazine-6-carbonitrile, 1-(2,2-dimethyl-1-oxopropoxy)-1,2,3,4-tetrahydro-; 1228666-61-2; Pivaloyl DHPO-carbonitrile; Advanced Pharmaceutical Intermediate 1228666-61-2
EINECS	Contact for details

Quality Control

Our production of 1-Pivaloyl-2,3-Dihydro-1H-Pyrido[2,3-B][1,4]-Oxazine-6-Carbonitrile adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere or with desiccant for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.