Description

1-(5-Fluoro-1H-Pyrrolo[2,3-B]Pyridin-4-Yl)Ethanone is a high-purity fluorinated heterocyclic building block of significant importance in modern pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of targeted small molecule therapeutics, particularly kinase inhibitors. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and advanced fine chemical manufacturers engaged in the discovery and production of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors targeting various oncology and inflammatory disease pathways.
• Chemical Biology Research: Used as a probe or scaffold in medicinal chemistry for structure-activity relationship (SAR) studies.
• API Synthesis: Employed in the multi-step synthesis of complex drug candidates containing the 7-azaindole (pyrrolopyridine) core.
• Preclinical Development: Serves as a starting material for producing compounds for pharmacological and toxicological evaluation.
• Custom Synthesis: Utilized by fine chemical suppliers for the contract manufacturing of proprietary compounds for clients.

Basic Information

Product Name	1-(5-Fluoro-1H-Pyrrolo[2,3-B]Pyridin-4-Yl)Ethanone
CAS No.	1228666-59-8
Molecular Formula	C9H7FN2O
Molecular Weight	178.16 g/mol
Synonyms	4-Acetyl-5-fluoro-7-azaindole; 5-Fluoro-4-acetyl-1H-pyrrolo[2,3-b]pyridine; 1-(5-Fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)ethan-1-one; 5-Fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl methyl ketone; 4-Acetyl-5-fluoro-1H-pyrrolo[2,3-b]pyridine; 1228666-59-8; 5-Fluoro-4-acetyl-7-azaindole
EINECS	Contact for details

Quality Control

Our 1-(5-Fluoro-1H-Pyrrolo[2,3-B]Pyridin-4-Yl)Ethanone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All batches are supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to industry best practices and can provide material that meets specific customer requirements for advanced synthetic work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.