Description

1-tert-Butyl 3-Methyl 4-Formyl-1H-Pyrrolo[2,3-B]-Pyridine-1,3-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its reactive formyl group and protected carboxylate functionalities. This compound matters as a critical building block for the synthesis of complex, nitrogen-containing heterocycles, enabling the development of novel active pharmaceutical ingredients (APIs). It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for drug discovery and development programs targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Organic Synthesis Building Block: Utilized in multi-step synthetic routes to construct fused pyrrolopyridine scaffolds, a privileged structure in medicinal chemistry.
• Research & Development (R&D): Serves as a critical reagent in academic and industrial research labs for exploring new chemical entities and reaction methodologies.
• Process Chemistry & Scale-Up: Used in the development and optimization of scalable synthetic routes from laboratory to pilot plant scale.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects.
• Agrochemical Research: Potential application as an intermediate in the development of new agrochemicals containing nitrogen heterocycles.

Basic Information

Item	Details
Product Name	1-tert-Butyl 3-Methyl 4-Formyl-1H-Pyrrolo[2,3-B]-Pyridine-1,3-Dicarboxylate
CAS No.	1228666-48-5
Molecular Formula	C16H18N2O5
Molecular Weight	318.33 g/mol
Synonyms	1-tert-Butyl 3-methyl 4-formyl-1H-pyrrolo[2,3-b]pyridine-1,3-dicarboxylate; 4-Formyl-1H-pyrrolo[2,3-b]pyridine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester; 1-(tert-Butoxycarbonyl)-3-(methoxycarbonyl)-4-formyl-1H-pyrrolo[2,3-b]pyridine; 1-Boc-3-methyl 4-formyl-1H-pyrrolo[2,3-b]pyridine-1,3-dicarboxylate; tert-Butyl methyl 4-formyl-1H-pyrrolo[2,3-b]pyridine-1,3-dicarboxylate
EINECS	Contact for details

Quality Control

Our 1-tert-Butyl 3-Methyl 4-Formyl-1H-Pyrrolo[2,3-B]-Pyridine-1,3-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), related substances, and physical characteristics are provided and available upon request. We support compliance with cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.