Description

tert-Butyl [(5-Fluoro-1H-Pyrrolo[2,3-B]Pyridin-4-Yl)Methyl]Carbamate is a high-purity, advanced pharmaceutical intermediate featuring a protected amine group on a fluorinated pyrrolopyridine scaffold. This compound is critical for medicinal chemistry research and development, enabling the synthesis of targeted bioactive molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel kinase inhibitors and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of small molecule drugs, particularly kinase inhibitors targeting various cancers and inflammatory diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its versatile, protected amine functionality.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component for constructing linkers or warheads in bifunctional degrader molecules.
• Chemical Biology Probes: Employed in the creation of labeled compounds for target identification and validation studies in biological systems.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.
• Academic Research: Used in university and institutional labs for fundamental research in heterocyclic chemistry and drug discovery methodologies.

Basic Information

Product Name	tert-Butyl [(5-Fluoro-1H-Pyrrolo[2,3-B]Pyridin-4-Yl)Methyl]Carbamate
CAS No.	1228666-42-9
Molecular Formula	C13H16FN3O2
Molecular Weight	265.29 g/mol
Synonyms	Boc-4-(aminomethyl)-5-fluoro-7-azaindole; tert-Butyl N-[(5-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)methyl]carbamate; 5-Fluoro-4-(Boc-aminomethyl)-7-azaindole; 1H-Pyrrolo[2,3-b]pyridine, 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-5-fluoro-; 4-(Boc-aminomethyl)-5-fluoro-1H-pyrrolo[2,3-b]pyridine; 5-Fluoro-4-((((tert-butoxy)carbonyl)amino)methyl)-1H-pyrrolo[2,3-b]pyridine; Boc-Aminomethyl-5-fluoro-7-azaindole
EINECS	Contact for details

Quality Control

Our tert-Butyl [(5-Fluoro-1H-Pyrrolo[2,3-B]Pyridin-4-Yl)Methyl]Carbamate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All batches are subjected to comprehensive analytical characterization including HPLC, NMR, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.