Description

3-(Benzyloxy)-2-(3-((tert-Butyldimethylsilyl)Oxy)-Prop-1-Yn-1-Yl)Pyridine is a high-purity, advanced pharmaceutical intermediate featuring a protected alkyne and silyl ether functional groups. This compound is critical for facilitating complex synthetic transformations, particularly in the construction of novel drug candidates and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Organic Synthesis: Serves as a versatile precursor in cross-coupling reactions (e.g., Sonogashira) and other metal-catalyzed transformations.
• Chemical Biology: Employed in the development of molecular probes and labeled compounds for biological target identification.
• Process Chemistry: Used in route scouting and scale-up development for efficient manufacturing of complex molecules.
• Academic Research: A valuable reagent for universities and research institutes exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	3-(Benzyloxy)-2-(3-((tert-Butyldimethylsilyl)Oxy)-Prop-1-Yn-1-Yl)Pyridine
CAS No.	1228666-14-5
Molecular Formula	C21H27NO2Si
Molecular Weight	353.53 g/mol
Synonyms	2-(3-((tert-Butyldimethylsilyl)oxy)prop-1-yn-1-yl)-3-(benzyloxy)pyridine; 3-Benzyloxy-2-[3-(tert-butyldimethylsiloxy)prop-1-ynyl]pyridine; 3-(Benzyloxy)-2-(3-((TBDMS)Oxy)prop-1-yn-1-yl)pyridine; 2-(3-(tert-Butyldimethylsilyloxy)prop-1-ynyl)-3-benzyloxypyridine; TBDMS-protected propargyl pyridine derivative; Pyridine, 3-(phenylmethoxy)-2-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-propyn-1-yl]-
EINECS	Contact for details

Quality Control

Our 3-(Benzyloxy)-2-(3-((tert-Butyldimethylsilyl)Oxy)-Prop-1-Yn-1-Yl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opened for use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.