Description

2,2-Dimethyl-1-(6-((Trimethylsilyl)Ethynyl)-2,3-Dihydro-1H-Pyrido[2,3-b][1,4]Oxazin-1-Yl)Propan-1-One is a high-value, specialized organic intermediate featuring a unique fused heterocyclic structure. This compound is critical for advanced research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) and functional materials. It is primarily sought after by pharmaceutical R&D teams, agrochemical innovators, and academic researchers working in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) due to its pyridooxazine core.
• Agrochemical Synthesis: Serves as a precursor for developing novel crop protection agents with potential insecticidal or fungicidal activity.
• Material Science: The trimethylsilylethynyl group makes it a candidate for constructing organic semiconductors or advanced polymers.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis and scale-up projects.

Basic Information

Product Name	2,2-Dimethyl-1-(6-((Trimethylsilyl)Ethynyl)-2,3-Dihydro-1H-Pyrido[2,3-b][1,4]Oxazin-1-Yl)Propan-1-One
CAS No.	1228666-09-8
Molecular Formula	C19H26N2O2Si
Molecular Weight	342.51 g/mol
Synonyms	1-(6-((Trimethylsilyl)ethynyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-1-yl)-2,2-dimethylpropan-1-one; 2,2-Dimethyl-1-(6-((trimethylsilyl)ethynyl)-3,4-dihydro-2H-pyrido[2,3-b][1,4]oxazin-1-yl)propan-1-one; CAS 1228666-09-8; TMS-Ethynyl Pyridooxazinone Derivative; Propan-1-one, 2,2-dimethyl-1-(6-((trimethylsilyl)ethynyl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-1-yl)-; 1H-Pyrido[2,3-b][1,4]oxazin-1-one derivative
EINECS	Contact for details

Quality Control

Our 2,2-Dimethyl-1-(6-((Trimethylsilyl)Ethynyl)-2,3-Dihydro-1H-Pyrido[2,3-b][1,4]Oxazin-1-Yl)Propan-1-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture, to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.